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Advances in immunopathogenesis of adult immune thrombocytopenia
Xinguang Liu, Yu Hou, Jun Peng
Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 418-424 doi: 10.1007/s11684-013-0297-8
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated accelerated platelet destruction and/or suppressed platelet production. Although the development of autoantibodies against platelet glycoproteins remains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immune modulation have been identified, and the pathways behind the immune-mediated destruction of platelets have opened new avenues for the design of specific immunotherapies in an attempt to reduce the platelet destruction. This review is primarily focused on the recent literature with respect to immunopathological mechanisms in patients with ITP.
Keywords: primary immune thrombocytopenia B lymphocytes T lymphocytes antigen-presenting cells cytokines
Xiaofeng Shi, Rong Ba, Haiyan You, Qian Jiang, Jiansong Huang, Jianhua Mao, Lanxiu Han, Shuo Zhang, Qin Zhuang, Xianqiu Yu, Lixia Wang, Yun Wang, Dongya Li, Wei Zhu, Yong Zhang, Yan Zhu, Xiaodong Xi
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 324-329 doi: 10.1007/s11684-017-0558-z
Keywords: splenic lymphoma with villous lymphocytes splenic marginal zone lymphoma transformation chromosome translocation
Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients
Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN
Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 187-190 doi: 10.1007/s11684-009-0033-6
Keywords: asthma airway inflammation peripheral blood lymphocyte Tim-3
Yifei Cheng,Yuhong Chen,Chenhua Yan,Yu Wang,Xiangyu Zhao,Yao Chen,Wei Han,Lanping Xu,Xiaohui Zhang,Kaiyan Liu,Shasha Wang,Lungji Chang,Lei Xiao,Xiaojun Huang
Engineering 2019, Volume 5, Issue 1, Pages 150-155 doi: 10.1016/j.eng.2018.12.006
Keywords: Donor-derived CD19-targeted T cell infusion Hematopoietic stem cell transplantation B cell acute lymphoblastic
Deubiquitinases as pivotal regulators of T cell functions
Xiao-Dong Yang, Shao-Cong Sun
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 451-462 doi: 10.1007/s11684-018-0651-y
T cells efficiently respond to foreign antigens to mediate immune responses against infections butDefect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activationAn emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversibleIt is now well recognized that DUBs are crucial regulators of T cell responses and serve as potentialThis review will discuss the recent progresses regarding the functions of DUBs in T cells.
Keywords: deubiquitinase ubiquitination T cell activation T cell differentiation T cell tolerance
Regulation of T cell immunity by cellular metabolism
Zhilin Hu, Qiang Zou, Bing Su
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 463-472 doi: 10.1007/s11684-018-0668-2
T cells are an important adaptive immune response arm that mediates cell-mediated immunity.T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effectorSpecific metabolic programs are tightly controlled to mediate T cell immune responses, and alterationsin T cell metabolism may result in many immunological disorders.in T cell metabolic programming during T cell homeostasis, differentiation, and function.
Keywords: T cell immunity metabolic pathways nutrient uptake metabolic checkpoints
Separation and extraction of bridge dynamic strain data
Baijian WU, Zhaoxia LI, Ying WANG, T. H. T. CHAN,
Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 4, Pages 395-400 doi: 10.1007/s11709-009-0049-7
Keywords: dynamic valuable separatrix strain/stress amplitude frequency
Carcinogens that induce the A:T>T:A nucleotide substitutions in the genome
Guangbiao Zhou, Xinchun Zhao
Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 236-238 doi: 10.1007/s11684-017-0611-y
Recently, Ng . reported that the A:T>T:A substitutions, proposed to be a signature of aristolochicof the patients’ exposure history is the key to determine the “culprit” of the A:T>T:A mutations.
Keywords: genomic signature carcinogen aristolochic acid tobacco smoke vinyl chloride hepatocellular carcinoma
Xuefu Wang, Zhigang Tian
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 262-268 doi: 10.1007/s11684-017-0584-x
γδ T cells display unique developmental, distributional, and functional patterns and canγδ T cells are enriched in the liver and exhibit liver-specific features.In this study, we review the properties of hepatic γδ T cells and summarize the roles ofγδ T cells in liver diseases.We believe that determining the properties and functions of γδ T cells in liver diseases
Keywords: γδT cells liver infection non-alcoholic fatty liver disease autoimmune hepatitis liver fibrosis and cirrhosis
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 69-82 doi: 10.1007/s11684-018-0677-1
Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapyThe low-efficacy problem can be resolved using T cell antigen receptor-engineered CAT (TCR-CAT).TCR-CATs delivered significantly better activation and cytotoxicity than the equivalent TCR-engineered TTCR-CAT may be a very good alternative to the expensive TCR-T, which is considered an effective personalized
Keywords: cytokine-activated T cells high-affinity T cell receptor cancer immunotherapy TCR-CAT
Ian T. RILEY
Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4, Pages 568-582 doi: 10.15302/J-FASE-2019270
Keywords: actinorrhizal trees agroforestry climate change ecosystem restoration
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies
Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 783-804 doi: 10.1007/s11684-021-0904-z
Keywords: CAR T cells hematological malignancies review
Chimeric antigen receptor T cell therapies for acute myeloid leukemia
Bin Gu, Jianhong Chu, Depei Wu
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 701-710 doi: 10.1007/s11684-020-0763-z
Keywords: acute myeloid leukemia CAR T immunotherapy
Innate and adaptive T cells in influenza disease
Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska
Frontiers of Medicine 2018, Volume 12, Issue 1, Pages 34-47 doi: 10.1007/s11684-017-0606-8
Keywords: influenza innate T cells CD4+ and CD8+ T cells vaccination
Treating wastewater under zero waste principle using wetland mesocosms
Ezzat, Mohammed T. Mohammed T.
Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1351-9
Keywords: Wastewater dynamic roughing filter Cyperus papyrus (L.) zeolite zero waste
Title Author Date Type Operation
Advances in immunopathogenesis of adult immune thrombocytopenia
Xinguang Liu, Yu Hou, Jun Peng
Journal Article
A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation
Xiaofeng Shi, Rong Ba, Haiyan You, Qian Jiang, Jiansong Huang, Jianhua Mao, Lanxiu Han, Shuo Zhang, Qin Zhuang, Xianqiu Yu, Lixia Wang, Yun Wang, Dongya Li, Wei Zhu, Yong Zhang, Yan Zhu, Xiaodong Xi
Journal Article
Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients
Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN
Journal Article
Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal ResidualDisease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation
Yifei Cheng,Yuhong Chen,Chenhua Yan,Yu Wang,Xiangyu Zhao,Yao Chen,Wei Han,Lanping Xu,Xiaohui Zhang,Kaiyan Liu,Shasha Wang,Lungji Chang,Lei Xiao,Xiaojun Huang
Journal Article
Deubiquitinases as pivotal regulators of T cell functions
Xiao-Dong Yang, Shao-Cong Sun
Journal Article
Separation and extraction of bridge dynamic strain data
Baijian WU, Zhaoxia LI, Ying WANG, T. H. T. CHAN,
Journal Article
Carcinogens that induce the A:T>T:A nucleotide substitutions in the genome
Guangbiao Zhou, Xinchun Zhao
Journal Article
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
Journal Article
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies
Journal Article
Chimeric antigen receptor T cell therapies for acute myeloid leukemia
Bin Gu, Jianhong Chu, Depei Wu
Journal Article
Innate and adaptive T cells in influenza disease
Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska
Journal Article